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Found 995 result(s)
BindingDB is a public, web-accessible knowledgebase of measured binding affinities, focusing chiefly on the interactions of proteins considered to be candidate drug-targets with ligands that are small, drug-like molecules. BindingDB supports medicinal chemistry and drug discovery via literature awareness and development of structure-activity relations (SAR and QSAR); validation of computational chemistry and molecular modeling approaches such as docking, scoring and free energy methods; chemical biology and chemical genomics; and basic studies of the physical chemistry of molecular recognition. BindingDB also includes a small collection of host-guest binding data of interest to chemists studying supramolecular systems. The data collection derives from a variety of measurement techniques, including enzyme inhibition and kinetics, isothermal titration calorimetry, NMR, and radioligand and competition assays. BindingDB includes data extracted from the literature and from US Patents by the BindingDB project, selected PubChem confirmatory BioAssays, and ChEMBL entries for which a well defined protein target ("TARGET_TYPE='PROTEIN'") is provided.
The BioCyc database collection of Pathway/Genome Databases (PGDBs) provides a reference on the genomes and metabolic pathways of thousands of sequenced organisms. BioCyc PGDBs are generated by software that predict the metabolic pathways of completely sequenced organisms, predict which genes code for missing enzymes in metabolic pathways, and predict operons. BioCyc also integrates information from other bioinformatics databases, such as protein feature and Gene Ontology information from UniProt. The BioCyc website provides a suite of software tools for database searching and visualization, for omics data analysis, and for comparative genomics and comparative pathway questions. From 2016 on, access to the EcoCyc and MetaCyc databases will remain free. Subscriptions to the other 7,600 BioCyc databases will be available to institutions (e.g., libraries), and to individuals. Access to licensed databases via: https://biocyc.org/Product-summary.shtml.
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The Repositorio de Datos de Investigación del Consejo Nacional de Investigaciones Científicas y Técnicas is a plataform of open access centralized in the storage, preservation and difusion of research data, which facilitates the access and reutilization of the scientific information created and self-archived by organism's researchers, fellowships and support staff.
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Androgen Receptor Gene Mutations Database is for all who are interested in mutations of the Androgen Receptor Gene. In light of the difficulty in getting new AR mutations published the curator will now accept new mutations that have not been published, provided that it is from a reputable research or clinical laboratory. The curator also strongly suggests that where possible, particularly in the case of new unique mutations that an attempt be made to at least confirm the pathogenicity of the putatative mutation, by showing that the mutation when transfected into a suitable expression system produces a mutant androgen receptor protein.
The Complex Portal is a manually curated, encyclopaedic resource of macromolecular complexes from a number of key model organisms, entered into the IntAct molecular interaction database (https://www.ebi.ac.uk/intact/). Data includes protein-only complexes as well as protein-small molecule and protein-nucleic acid complexes. All complexes are derived from physical molecular interaction evidences extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background. All complexes are tagged with Evidence and Conclusion Ontology codes to indicate the type of evidence available for each entry.
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The nature of the ‘Bridge of Data’ project is to design and build a platform that allows collecting, searching, analyzing and sharing open research data and to provide it with unique data collected from the three most important Pomeranian universities: Gdańsk University of Technology, Medical University of Gdańsk and the University of Gdańsk. These data will be made available free of charge to the scientific community, entrepreneurs and the public. A bridge will be built to allow reuse of Open Research Data. The available research data will be described by standards developed by dedicated, experienced scientific teams. The metadata will allow other external computer systems to interpret the collected data. ORD descriptions will also include data reuse or reduction scenarios to facilitate further processing.
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The mission of the platform is to enable access for academic projects towards experiments in high-throughput without loss of IP and on a cost basis, which does not restrict access towards HTS usage. The FMP hosts the central open access technology platform of EU-OPENSCREEN, the ChemBioNet and theHelmholtz-Initiative für Wirkstoffforschung, the Screening Unit. The Unit serves for systematic screening of large compound or genome-wide RNAi libraries with state-of-the-art equipment like automated microscopes and microfluidic systems. The Screening Unit is part of the Chemical Biology Platform of the FMP also supported by the MDC. See also: https://www.mdc-berlin.de/screening-unit
INTEGRALL is a web-based platform dedicated to compile information on integrons and designed to organize all the data available for these genetic structures. INTEGRALL provides a public genetic repository for sequence data and nomenclature and offers to scientists an easy and interactive access to integron's DNA sequences, their molecular arrangements as well as their genetic contexts.
The PRIDE PRoteomics IDEntifications database is a centralized, standards compliant, public data repository for proteomics data, including protein and peptide identifications, post-translational modifications and supporting spectral evidence. PRIDE encourages and welcomes direct user submissions of mass spectrometry data to be published in peer-reviewed publications.
KADoNiS-p database: The KADoNiS project is an online database for cross sections relevant to the s-process and p-process (γ-process). The present p-process library includes all available experimental data from (p,γ), (p,n), (α,γ), (α,n), and (α,p) reactions between 70Ge and 209Bi in or close to the respective Gamow window.
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RADAR4KIT enables KIT researchers to manage, archive, share in project teams and publish their research data in a repository. It allows users to compile research data from completed scientific studies and projects into data packages, describe them with metadata, store them permanently and archive them or make them publicly accessible if required. Published data are given a persistent identifier (DOI) and can thus be found internationally and are also referenced in KITopen. The operator is the Karlsruhe Institute of Technology (KIT). RADAR4KIT is based on the RADAR service offered by FIZ Karlsruhe. The data is stored exclusively on the KIT IT infrastructure at the Steinbuch Centre for Computing (SCC).
The European Mouse Mutant Archive – EMMA is a non-profit repository for the collection, archiving (via cryopreservation) and distribution of relevant mutant mouse strains essential for basic biomedical research. The laboratory mouse is the most important mammalian model for studying genetic and multi-factorial diseases in man. The comprehensive physical and data resources of EMMA support basic biomedical and preclinical research, and the available research tools and mouse models of human disease offer the opportunity to develop a better understanding of molecular disease mechanisms and may provide the foundation for the development of diagnostic, prognostic and therapeutic strategies.
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<<<!!!<<< This repository is no longer available. PLEASE NOTE: Unfortunately, the Hustedt collection cannot be used at the moment. Since the collection was previously located in our section, this page can still be found here. We hope to be able to provide information on the further use of the collection shortly. https://www.awi.de/en/science/biosciences/polar-biological-oceanography/main-research-focus/hustedt-diatom-study-centre.html >>>!!!>>>
The Medical Expenditure Panel Survey (MEPS) is a set of large-scale surveys of families and individuals, their medical providers, and employers across the United States. MEPS is the most complete source of data on the cost and use of health care and health insurance coverage.
The Osteoarthritis Initiative (OAI) is a multi-center, longitudinal, prospective observational study of knee osteoarthritis (OA). The overall aim of the OAI is to develop a public domain research resource to facilitate the scientific evaluation of biomarkers for osteoarthritis as potential surrogate endpoints for disease onset and progression.