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CryptoDB is an integrated genomic and functional genomic database for the parasite Cryptosporidium and other related genera. CryptoDB integrates whole genome sequence and annotation along with experimental data and environmental isolate sequences provided by community researchers. The database includes supplemental bioinformatics analyses and a web interface for data-mining.
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The purpose of the Canadian Urban Data Repository (CUDR) is to provide a “home” for urban datasets. While primarily focused on datasets created by academe, it will also contain datasets created by NGOs, governments, citizens, and industry. Datasets stored in the repository will be open-access and will not contain personally identifiable information. The purpose of the Canadian Urban Data Catalogue (CUDC) is to enhance the awareness of urban datasets that exist across Canada by providing a catalogue of Canadian and Canadian-created urban datasets. It will catalogue datasets available in CUDR and external datasets available on other platforms and as web services. These external datasets may be open or closed. CUDC uses a rich metadata model that supports the documentation and search for datasets relevant to a user’s needs. Catalogue entry metadata may be exported and imported from/to CUDC.
Giardia lamblia is a significant, environmentally transmitted, human pathogen and an amitochondriate protist. It is a major contributor to the enormous worldwide burden of human diarrheal diseases, yet the basic biology of this parasite is not well understood. No virulence factor has been identified. The Giardia lamblia genome contains only 12 million base pairs distributed onto five chromosomes. Its analysis promises to provide insights about the origins of nuclear genome organization, the metabolic pathways used by parasitic protists, and the cellular biology of host interaction and avoidance of host immune systems. Since the divergence of Giardia lamblia lies close to the transition between eukaryotes and prokaryotes in universal ribosomal RNA phylogenies, it is a valuable, if not unique, model for gaining basic insights into genetic innovations that led to formation of eukaryotic cells. In evolutionary terms, the divergence of this organism is at least twice as ancient as the common ancestor for yeast and man. A detailed study of its genome will provide insights into an early evolutionary stage of eukaryotic chromosome organization as well as other aspects of the prokaryotic / eukaryotic divergence.