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Found 488 result(s)
The 1000 Genomes Project is an international collaboration to produce an extensive public catalog of human genetic variation, including SNPs and structural variants, and their haplotype contexts. This resource will support genome-wide association studies and other medical research studies. The genomes of about 2500 unidentified people from about 25 populations around the world will be sequenced using next-generation sequencing technologies. The results of the study will be freely and publicly accessible to researchers worldwide. The International Genome Sample Resource (IGSR) has been established at EMBL-EBI to continue supporting data generated by the 1000 Genomes Project, supplemented with new data and new analysis.
AceView provides a curated, comprehensive and non-redundant sequence representation of all public mRNA sequences (mRNAs from GenBank or RefSeq, and single pass cDNA sequences from dbEST and Trace). These experimental cDNA sequences are first co-aligned on the genome then clustered into a minimal number of alternative transcript variants and grouped into genes. Using exhaustively and with high quality standards the available cDNA sequences evidences the beauty and complexity of mammals’ transcriptome, and the relative simplicity of the nematode and plant transcriptomes. Genes are classified according to their inferred coding potential; many presumably non-coding genes are discovered. Genes are named by Entrez Gene names when available, else by AceView gene names, stable from release to release. Alternative features (promoters, introns and exons, polyadenylation signals) and coding potential, including motifs, domains, and homologies are annotated in depth; tissues where expression has been observed are listed in order of representation; diseases, phenotypes, pathways, functions, localization or interactions are annotated by mining selected sources, in particular PubMed, GAD and Entrez Gene, and also by performing manual annotation, especially in the worm. In this way, both the anatomy and physiology of the experimentally cDNA supported human, mouse and nematode genes are thoroughly annotated.
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TERN's AEKOS data portal is the original gateway to Australian ecology data. It is a ‘data and research methods’ data portal for Australia’s land-dwelling plants, animals and their environments. The primary focus of data content is raw co-located ‘species and environment’ ecological survey data that has been collected at the ‘plot’ level to describe biodiversity, its patterns and ecological processes. It is openly accessible with standard discovery metadata and user-oriented, contextual metadata critical for data reuse. Our services support the ecosystem science community, land managers and governments seeking to publish under COPE publishing ethics and the FAIR data publishing principles. AEKOS is registered with Thomson & Reuters Data Citation Index and is a recommended repository of Nature Publishing’s Scientific Data. There are currently 97,037 sites covering mostly plant biodiversity and co-located environmental data of Australia. The AEKOS initiative is supported by TERN (tern.org.au), hosted by The University of Adelaide and funded by the Australian Government’s National Research Infrastructure for Australia.
Alaska Ocean Observing System (AOOS) provides ocean and coastal observations data. The AOOS is governed by the Integrated Ocean Observing System (IOOS) which is a partnership among federal, regional, academic and private sector groups. The Ocean Data Explorer contains scientific and management information including real-time sensor feeds, operational oceanographic and atmospheric models, satellite observations and GIS data sets that describe the biological, chemical and physical characteristics of Alaska and its surrounding waters. This map offers many new updated features that build upon the existing data system.
The USGS Alaska Region has the largest geographic extent of the seven regional units within the USGS and represents a dynamic landscape of great natural wonder. It is a transforming landscape shaped by volcanoes, earthquakes, major rivers, and glaciers and a strategic landscape of yet untapped mineral and energy resources. The Region conducts research to help inform management of the extensive national parks and wildlife refuges of the far north and the international birds, fish, and marine mammals that migrate to these lands and waters; informs national Arctic energy policy through research on the National Petroleum Reserve-Alaska and the U.S. Outer Continental Shelf; and provides science to understand, help respond to and mitigate impacts from natural hazards. This work is accomplished in part by the Region's two Science Centers headquartered in Anchorage, the Alaska Science Center and the Volcano Science Center.
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ALEXA is a microarray design platform for 'alternative expression analysis'. This platform facilitates the design of expression arrays for analysis of mRNA isoforms generated from a single locus by the use of alternative transcription initiation, splicing and polyadenylation sites. We use the term 'ALEXA' to describe a collection of novel genomic methods for 'alternative expression' analysis. 'Alternative expression' refers to the identification and quantification of alternative mRNA transcripts produced by alternative transcript initiation, alternative splicing and alternative polyadenylation. This website provides supplementary materials, source code and other downloads for recent publications describing our studies of alternative expression (AE). Most recently we have developed a method, 'ALEXA-Seq' and associated resources for alternative expression analysis by massively parallel RNA sequencing.
AlgaeBase is a database of information on algae that includes terrestrial, marine and freshwater organisms. At present, the data for the marine algae, particularly seaweeds, are the most complete.
The Allele Frequency Net Database (AFND) is a public database which contains frequency information of several immune genes such as Human Leukocyte Antigens (HLA), Killer-cell Immunoglobulin-like Receptors (KIR), Major histocompatibility complex class I chain-related (MIC) genes, and a number of cytokine gene polymorphisms. The Allele Frequency Net Database (AFND) provides a central source, freely available to all, for the storage of allele frequencies from different polymorphic areas in the Human Genome. Users can contribute the results of their work into one common database and can perform database searches on information already available. We have currently collected data in allele, haplotype and genotype format. However, the success of this website will depend on you to contribute your data.
The Allen Brain Atlas provides a unique online public resource integrating extensive gene expression data, connectivity data and neuroanatomical information with powerful search and viewing tools for the adult and developing brain in mouse, human and non-human primate
ALSoD is a freely available database that has been transformed from a single gene storage facility recording mutations in the SOD1 gene to a multigene ALS bioinformatics repository and analytical instrument combining genotype, phenotype, and geographical information with associated analysis tools. These include a comparison tool to evaluate genes side by side or jointly with user configurable features, a pathogenicity prediction tool using a combination of computational approaches to distinguish variants with nonfunctional characteristics from disease-associated mutations with more dangerous consequences, and a credibility tool to enable ALS researchers to objectively assess the evidence for gene causation in ALS. Furthermore, integration of external tools, systems for feedback, annotation by users, and two-way links to collaborators hosting complementary databases further enhance the functionality of ALSoD.
AmphibiaWeb is an online system enabling any user to search and retrieve information relating to amphibian biology and conservation. This site was motivated by the global declines of amphibians, the study of which has been hindered by the lack of multidisplinary studies and a lack of coordination in monitoring, in field studies, and in lab studies. We hope AmphibiaWeb will encourage a shared vision to collaboratively face the challenge of global amphibian declines and the conservation of remaining amphibians and their habitats.
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Androgen Receptor Gene Mutations Database is for all who are interested in mutations of the Androgen Receptor Gene. In light of the difficulty in getting new AR mutations published the curator will now accept new mutations that have not been published, provided that it is from a reputable research or clinical laboratory. The curator also strongly suggests that where possible, particularly in the case of new unique mutations that an attempt be made to at least confirm the pathogenicity of the putatative mutation, by showing that the mutation when transfected into a suitable expression system produces a mutant androgen receptor protein.
The database aims to bridge the gap between agent repositories and studies documenting the effect of antimicrobial combination therapies. Most notably, our primary aim is to compile data on the combination of antimicrobial agents, namely natural products such as AMP. To meet this purpose, we have developed a data curation workflow that combines text mining, manual expert curation and graph analysis and supports the reconstruction of AMP-Drug combinations.
The Australian National University undertake work to collect and publish metadata about research data held by ANU, and in the case of four discipline areas, Earth Sciences, Astronomy, Phenomics and Digital Humanities to develop pipelines and tools to enable the publication of research data using a common and repeatable approach. Aims and outcomes: To identify and describe research data held at ANU, to develop a consistent approach to the publication of metadata on the University's data holdings: Identification and curation of significant orphan data sets that might otherwise be lost or inadvertently destroyed, to develop a culture of data data sharing and data re-use.
Apollo (previously DSpace@Cambridge) is the University of Cambridge’s Institutional Repository (IR), preserving and providing access to content created by members of the University. The repository stores a range of content and provides different levels of access, but its primary focus is on providing open access to the University’s research publications.
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SeSam is an outstanding international collection of recent and fossil animals and plants from all over the world. It also holds an important specialized library. The really substantial data of this collection constitute the basis of every taxonomic-systematical, ecological, biogeographical or biostratigraphical fundamental research as well as every practical environmental research. Because of its historical referencings this collection is also a precious cultural treasure that generates the often expensive heavy mission of its conservation. The new system is called AQUiLA.
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ArachnoServer is a manually curated database containing information on the sequence, three-dimensional structure, and biological activity of protein toxins derived from spider venom. Spiders are the largest group of venomous animals and they are predicted to contain by far the largest number of pharmacologically active peptide toxins (Escoubas et al., 2006). ArachnoServer has been custom-built so that a wide range of biological scientists, including neuroscientists, pharmacologists, and toxinologists, can readily access key data relevant to their discipline without being overwhelmed by extraneous information.
ASAP (a systematic annotation package for community analysis of genomes) is a relational database and web interface developed to store, update and distribute genome sequence data and gene expression data collected by or in collaboration with researchers at the University of Wisconsin - Madison. ASAP was designed to facilitate ongoing community annotation of genomes and to grow with genome projects as they move from the preliminary data stage through post-sequencing functional analysis. The ASAP database includes multiple genome sequences at various stages of analysis, and gene expression data from preliminary experiments.
>>>>!!!!<<<< AspGD data are being integrated into FungiDB. Please click here for additional details http://fungidb.org/ . Discussion of how to maximize the value of FungiDB for the Aspergillus research community will be a major topic at the upcoming AsperFest12 meeting at Asilomar (March 16-17, 2015). >>>>!!!!<<<< AspGD is an organized collection of genetic and molecular biological information about the filamentous fungi of the genus Aspergillus. Among its many species, the genus contains an excellent model organism (A. nidulans, or its teleomorph Emericella nidulans), an important pathogen of the immunocompromised (A. fumigatus), an agriculturally important toxin producer (A. flavus), and two species used in industrial processes (A. niger and A. oryzae). AspGD contains information about genes and proteins of multiple Aspergillus species; descriptions and classifications of their biological roles, molecular functions, and subcellular localizations; gene, protein, and chromosome sequence information; tools for analysis and comparison of sequences; and links to literature information; as well as a multispecies comparative genomics browser tool (Sybil) for exploration of orthology and synteny across multiple sequenced Aspergillus species.
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The Atlantic Canada Conservation Data Centre (ACCDC) maintains comprehensive lists of plant and animal species. The Atlantic CDC has geo-located records of species occurrences and records of extremely rare to uncommon species in the Atlantic region, including New Brunswick, Nova Scotia, Prince Edward Island, Newfoundland, and Labrador. The Atlantic CDC also maintains biological and other types of data in a variety of linked databases.
The Atlas of Living Australia (ALA) combines and provides scientifically collected data from a wide range of sources such as museums, herbaria, community groups, government departments, individuals and universities. Data records consist of images, literature, molecular DNA data, identification keys, species interaction data, species profile data, nomenclature, source data, conservation indicators, and spatial data.
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The Australian Antarctic Data Centre (AADC) provides data collection and data management services in Australia's Antarctic Science Program. The AADC manages science data from Australia's Antarctic research, maps Australia's areas of interest in the Antarctic region, manages Australia's Antarctic state of the environment reporting, and provides advice and education and a range of other products.
The Australian Drosophila Ecology and Evolution Resource (ADEER) from the Hoffmann lab and other contributors is a nationally significant life science collection. The Drosophila Clinal Data Collection contains data on populations along the eastern coast of Australia. It remains an excellent resource for understanding past and future evolutionary responses to climate change. The Drosophila Genomic Data Collection hosts Drosophila genomes sequenced as part of the Genomic Basis for Adaptation to Climate Change Project. 23 genomes have been sequenced as part of this project. Currently assemblies and annotations are available for Drosophila birchii, D. bunnanda, D. hydei, and D. repleta. The Drosophila Species Distribution Data Collection contains distribution data of nine drosophilid species that have been collected in Australia by the Hoffmann lab and other research groups between 1924 and 2005. More than 300 drosophilid species have been identified in the tropical and temperate forests located on the east coast of Australia. Many species are restricted to the tropics, a few are temperate specialists, and some have broad distributions across climatic regions. Their varied distribution along the tropical - temperate cline provide a powerful tool for studying climate adaptation and species distribution limits.