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Found 3 result(s)

Project Achilles

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Project Achilles is a systematic effort aimed at identifying and cataloging genetic vulnerabilities across hundreds of genomically characterized cancer cell lines. The project uses genome-wide genetic perturbation reagents (shRNAs or Cas9/sgRNAs) to silence or knock-out individual genes and identify those genes that affect cell survival. Large-scale functional screening of cancer cell lines provides a complementary approach to those studies that aim to characterize the molecular alterations (e.g. mutations, copy number alterations) of primary tumors, such as The Cancer Genome Atlas (TCGA). The overall goal of the project is to identify cancer genetic dependencies and link them to molecular characteristics in order to prioritize targets for therapeutic development and identify the patient population that might benefit from such targets. Project Achilles data is hosted on the Cancer Dependency Map Portal (DepMap) where it has been harmonized with our genomics and cellular models data. You can access the latest and all past datasets here: https://depmap.org/portal/download/all/

Pombase

The scientific resource for fission yeast

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PomBase is a comprehensive database for the fission yeast Schizosaccharomyces pombe, providing structural and functional annotation, literature curation and access to large-scale data sets.

Galaxy Zoo

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Galaxies, made up of billions of stars like our Sun, are the beacons that light up the structure of even the most distant regions in space. Not all galaxies are alike, however. They come in very different shapes and have very different properties; they may be large or small, old or young, red or blue, regular or confused, luminous or faint, dusty or gas-poor, rotating or static, round or disky, and they live either in splendid isolation or in clusters. In other words, the universe contains a very colourful and diverse zoo of galaxies. For almost a century, astronomers have been discussing how galaxies should be classified and how they relate to each other in an attempt to attack the big question of how galaxies form. Galaxy Zoo (Lintott et al. 2008, 2011) pioneered a novel method for performing large-scale visual classifications of survey datasets. This webpage allows anyone to download the resulting GZ classifications of galaxies in the project.