MetaCyc is a curated database of experimentally elucidated metabolic pathways from all domains of life.
MetaCyc contains pathways involved in both primary and secondary metabolism, as well as associated metabolites, reactions, enzymes, and genes. The goal of MetaCyc is to catalog the universe of metabolism by storing a representative sample of each experimentally elucidated pathway.
MetaCyc applications include: Online encyclopedia of metabolism, Prediction of metabolic pathways in sequenced genomes, Support metabolic engineering via enzyme database, Metabolite database aids. metabolomics research.
MetaCyc is covered by Thomson Reuters Data Citation Index. MetaCyc contains links to many other bioinformatics DBs:
Pathways link to EcoCyc, the University of Minnesota Biocatalysis/Biodegradation Database, the KEGG Ligand database, and the Soybase database.
Proteins contain unification links to UniProt/Swiss-Prot, FlyBase, DictyBase, DIP, DisProt, STRING, EuPathDB, PhosphoSite, PRIDE, PROSITE, SMR, and MINT.
Proteins also contain relationship links to SMART, PANTHER, ProDom, PRINTS, CAZy, PDB, Pfam, and InterPro.
Reactions link to ENZYME, KEGG, BRENDA, Rhea, and IUBMB.
Chemical compounds link to PubChem, NCI Open Database, ChEBI, KEGG, Chemical Abstracts, Wikipedia ChemSpider, DrugBank, BiGG and KEGG Glycan.
Genes link to NCBI Entrez nucleotide and gene databases, to TAIR (The Arabidopsis Information Resource) and to the Coli Genetic Stock Center.
All types of objects may contain literature citations, which link to PubMed when available.