Repository details

Rhea

Name of repository
Rhea
Repository URL
https://www.rhea-db.org/
Subject(s)
Description
Rhea is a freely available and comprehensive resource of expert-curated biochemical reactions. It has been designed to provide a non-redundant set of chemical transformations for applications such as the functional annotation of enzymes, pathway inference and metabolic network reconstruction. There are three types of reaction participants (reactants and products): Small molecules, Rhea polymers, Generic compounds. All three types of reaction participants are linked to the ChEBI database (Chemical Entities of Biological Interest) which provides detailed information about structure, formula and charge. Rhea provides built-in validations that ensure both mass and charge balance of the reactions. We have populated the database with the reactions found in the enzyme classification (i.e. in the IntEnz and ENZYME databases), extending it with additional known reactions of biological interest. While the main focus of Rhea is enzyme-catalysed reactions, other biochemical reactions (including those that are often termed "spontaneous") also are included.
Contact(s)
Content type(s)
Keyword(s)
Persistent identifier(s) of the repository
Repository size
17.783 reactions with 14.654 unique compounds from 18.435 unique references
Repository type(s)
  • disciplinary
Mission statement for designated community
https://www.rhea-db.org/help/what-is-rhea
Research data repository language(s)
  • English
Data and/or service provider
  • dataProvider
  • serviceProvider

Institutions (3)

Institution
European Commission, Research & Innovation, Seventh Framework Programm - FP7
Institution
Country
European Union
Type(s) of responsibility
  • funding
Type of institution
non-profit
Institution
European Molecular Biology Laboratory, European Bioinformatics Institute
Additional name(s)
  • EMBL-EBI
Institution
Country
European Union
Type(s) of responsibility
  • general
Type of institution
non-profit
Institution
Swiss Institute of Bioinformatics, Swiss-Prot Group
Additional name(s)
  • SIB
Country
Switzerland
Type(s) of responsibility
  • general
Type of institution
non-profit

Policies (2)

Policy Name
Rhea user guide
Policy Name
Reaction curation

Database access

Type of access to research data repository
open

Database licenses (1)

Database License
Apache License 2.0

Data access (1)

Type of access to data
open

Data licenses (2)

DataLicense
CC
DataLicense
Copyrights

Data upload (1)

Type of data upload
restricted
Data upload restriction type(s)
  • registration

Data upload license (1)

Data upload license name
Rhea at sourceforge
Versioning
yes
Data citation guideline
https://www.rhea-db.org/help/publications
Enhanced Publication
yes
Quality management
yes

Application programming interfaces (3)

Type
SPARQL
Url
https://sparql.rhea-db.org/sparql
Type
FTP
Url
https://ftp.expasy.org/databases/rhea/
Type
REST
Url
https://www.rhea-db.org/help/rest-api

Remarks

Remarks
The database is extensively cross-referenced. The ChEBI index is used to resolve any synonyms or cross references. Reactions are currently linked to the EC list, KEGG and MetaCyc, and the reactions will be used in the IntEnz database and in all relevant UniProtKB entries. Furthermore, the reactions will also be used in the UniPathway database to generate pathways and metabolic networks.
Entry date
2014-05-19
Last update
2025-09-23
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Cite this re3data.org record:

re3data.org: Rhea; editing status 2025-09-23; re3data.org - Registry of Research Data Repositories. https://doi.org/10.17616/R3332H last accessed: 2025-10-12