The Open Biomedical Imaging Archive (OBIA) is a repository for archiving biomedical imaging and related clinical data in a common DICOM format. OBIA adopts five data objects (Collection, Individual, Study, Series, and Image) for data organization, accepts the submission of biomedical images of multiple modalities, organs, and diseases. In order to protect personal privacy, OBIA has formulated a unified de-identification and quality control process based on the DICOM standard. In addition, OBIA provides friendly and intuitive web interface for data submission, browsing and retrieval, as well as image retrieval. As of November 2024, OBIA has housed data for a total of 991 individuals, 4244 studies, 24,701 series, and 1,946,305 images covering 9 modalities and 30 anatomical sites. Representative imaging modalities are MR, CT, and DX. Anatomical sites include the chest, pelvis, abdomen, head and liver. OBIA offering two types of data accessibility: open access and controlled access. Data access permissions for controlled-access datasets are managed by the submitter. Collectively, OBIA provides a reliable platform for biomedical imaging data management and offers free open access to all publicly available data to support research activities throughout the world.