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BioSimulations is a web application for sharing and re-using biomodels, simulations, and visualizations of simulations results. BioSimulations supports a wide range of modeling frameworks (e.g., kinetic, constraint-based, and logical modeling), model formats (e.g., BNGL, CellML, SBML), and simulation tools (e.g., COPASI, libRoadRunner/tellurium, NFSim, VCell). BioSimulations aims to help researchers discover published models that might be useful for their research and quickly try them via a simple web-based interface.
OpenWorm aims to build the first comprehensive computational model of the Caenorhabditis elegans (C. elegans), a microscopic roundworm. With only a thousand cells, it solves basic problems such as feeding, mate-finding and predator avoidance. Despite being extremely well studied in biology, this organism still eludes a deep, principled understanding of its biology. We are using a bottom-up approach, aimed at observing the worm behaviour emerge from a simulation of data derived from scientific experiments carried out over the past decade. To do so we are incorporating the data available in the scientific community into software models. We are engineering Geppetto and Sibernetic, open-source simulation platforms, to be able to run these different models in concert. We are also forging new collaborations with universities and research institutes to collect data that fill in the gaps All the code we produce in the OpenWorm project is Open Source and available on GitHub.
The DesignSafe Data Depot Repository (DDR) is the platform for curation and publication of datasets generated in the course of natural hazards research. The DDR is an open access data repository that enables data producers to safely store, share, organize, and describe research data, towards permanent publication, distribution, and impact evaluation. The DDR allows data consumers to discover, search for, access, and reuse published data in an effort to accelerate research discovery. It is a component of the DesignSafe cyberinfrastructure, which represents a comprehensive research environment that provides cloud-based tools to manage, analyze, curate, and publish critical data for research to understand the impacts of natural hazards. DesignSafe is part of the NSF-supported Natural Hazards Engineering Research Infrastructure (NHERI), and aligns with its mission to provide the natural hazards research community with open access, shared-use scholarship, education, and community resources aimed at supporting civil and social infrastructure prior to, during, and following natural disasters. It serves a broad national and international audience of natural hazard researchers (both engineers and social scientists), students, practitioners, policy makers, as well as the general public. It has been in operation since 2016, and also provides access to legacy data dating from about 2005. These legacy data were generated as part of the NSF-supported Network for Earthquake Engineering Simulation (NEES), a predecessor to NHERI. Legacy data and metadata belonging to NEES were transferred to the DDR for continuous preservation and access.