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Found 91 result(s)
With ARS - Antimicrobial Resistance Surveillance in Germany - the infrastructure for a nationwide surveillance of antimicrobial resistance has been established, which covers both the inpatient medical care and the ambulatory care sector. This is intended to reliable data on the epidemiology of antimicrobial resistance in Germany and differential statements provided by structural features of the health care and by region are possible. ARS is designed as a laboratory-based surveillance system for continuous collection of resistance data from routine for the full range of clinically relevant bacterial pathogens. Project participants and thus data suppliers are laboratories that analyze samples of medical facilities and doctors' offices microbiologically.
The PLANKTON*NET data provider at the Alfred Wegener Institute for Polar and Marine Research is an open access repository for plankton-related information. It covers all types of phytoplankton and zooplankton from marine and freshwater areas. PLANKTON*NET's greatest strength is its comprehensiveness as for the different taxa image information as well as taxonomic descriptions can be archived. PLANKTON*NET also contains a glossary with accompanying images to illustrate the term definitions. PLANKTON*NET therefore presents a vital tool for the preservation of historic data sets as well as the archival of current research results. Because interoperability with international biodiversity data providers (e.g. GBIF) is one of our aims, the architecture behind the new planktonnet@awi repository is observation centric and allows for mulitple assignment of assets (images, references, animations, etc) to any given observation. In addition, images can be grouped in sets and/or assigned tags to satisfy user-specific needs . Sets (and respective images) of relevance to the scientific community and/or general public have been assigned a persistant digital object identifier (DOI) for the purpose of long-term preservation (e.g. set ""Plankton*Net celebrates 50 years of Roman Treaties"", handle: 10013/de.awi.planktonnet.set.495)"
A human interactome map. The sequencing of the human genome has provided a surprisingly small number of genes, indicating that the complex organization of life is not reflected in the gene number but, rather, in the gene products – that is, in the proteins. These macromolecules regulate the vast majority of cellular processes by their ability to communicate with each other and to assemble into larger functional units. Therefore, the systematic analysis of protein-protein interactions is fundamental for the understanding of protein function, cellular processes and, ultimately, the complexity of life. Moreover, interactome maps are particularly needed to link new proteins to disease pathways and the identification of novel drug targets.
The Bavarian Natural History Collections (Staatliche Naturwissenschaftliche Sammlungen Bayerns, SNSB) are a research institution for natural history in Bavaria. They encompass five State Collections (zoology, botany, paleontology and geology, mineralogy, anthropology and paleoanatomy), the Botanical Garden Munich-Nymphenburg and eight museums with public exhibitions in Munich, Bamberg, Bayreuth, Eichstätt and Nördlingen. Our research focuses mainly on the past and present bio- and geodiversity and the evolution of animals and plants. To achieve this we have large scientific collections (almost 35,000,000 specimens). Collections and museums also play an instrumental role in public and academic education.
The JenAge Ageing Factor Database AgeFactDB is aimed at the collection and integration of ageing phenotype and lifespan data. Ageing factors are genes, chemical compounds or other factors such as dietary restriction, for example. In a first step ageing-related data are primarily taken from existing databases. In addition, new ageing-related information is included both by manual and automatic information extraction from the scientific literature. Based on a homology analysis, AgeFactDB also includes genes that are homologous to known ageing-related genes. These homologs are considered as candidate or putative ageing-related genes.
The RAMEDIS system is a platform independent, web-based information system for rare metabolic diseases based on filed case reports. It was developed in close cooperation with clinical partners to allow them to collect information on rare metabolic diseases with extensive details, e.g. about occurring symptoms, laboratory findings, therapy and molecular data.
STRING is a database of known and predicted protein interactions. The interactions include direct (physical) and indirect (functional) associations; they are derived from four sources: - Genomic Context - High-throughput Experiments - (Conserved) Coexpression - Previous Knowledge STRING quantitatively integrates interaction data from these sources for a large number of organisms, and transfers information between these organisms where applicable.
GeoReM is a Max Planck Institute database for reference materials of geological and environmental interest, such as rock powders, synthetic and natural glasses as well as mineral, isotopic, biological, river water and seawater reference materials. GeoReM contains published analytical data and compilation values (major and trace element concentrations and mass fractions, radiogenic and stable isotope ratios). GeoReM contains all important metadata about the analytical values such as uncertainty, analytical method and laboratory. Sample information and references are also included. GeoReM complements the three earthchem databases: GEOROC, NAVDAT and PETDB.
The Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) and the German Plant Phenotyping Network (DPPN) has jointly initiated the Plant Genomics and Phenomics Research Data Repository (PGP) as infrastructure to comprehensively publish plant research data []. This covers in particular these cross-domain data sets that are not being published in central repositories because of its huge volume, unsupported data domain or scope, like image collections from plant phenotyping and microscopy, unassembled sequences, genotyping data, visualizations of complex morphological plant models, movies plant 3-D models, raw data from mass spectrometry, software, and documents. Accepted data is published as citable DOIs and core set of technical metadata is registered at DataCite. The used e!DAL-embedded Web frontend generates for each data set a landing page and supports an interactive exploration of available datasets. This long-term stable access to plant genomic and phenomic primary data records across domains and laboratories in one repository can empower researchers to reproduce already published analysis results as well as performing subsequent, advanced studies.
BRENDA is the main collection of enzyme functional data available to the scientific community worldwide. The enzymes are classified according to the Enzyme Commission list of enzymes. It is available free of charge for via the internet ( and as an in-house database for commercial users (requests to our distributor Biobase). The enzymes are classified according to the Enzyme Commission list of enzymes. Some 5000 "different" enzymes are covered. Frequently enzymes with very different properties are included under the same EC number. BRENDA includes biochemical and molecular information on classification, nomenclature, reaction, specificity, functional parameters, occurrence, enzyme structure, application, engineering, stability, disease, isolation, and preparation. The database also provides additional information on ligands, which function as natural or in vitro substrates/products, inhibitors, activating compounds, cofactors, bound metals, and other attributes.
The project brings together national key players providing environmentally related biological data and services to develop the ‘German Federation for Biological Data' (GFBio). The overall goal is to provide a sustainable, service oriented, national data infrastructure facilitating data sharing and stimulating data intensive science in the fields of biological and environmental research.
Human biomaterial banks (short: biobanks) are collections of human body substances (i.e. blood, DNA, urine or tissue) connected with disease specific information. This allow for research of relations between deseases and underlying (molecular) modifications and paves the way for developing target-oriented therapies ("personalized medicine"). The biobank material arises from samples taken for therapeutical or diagnostic reasons or is extracted in the context of clinical trials. An approval for usage by the patient is always needed prior to any research activities.
As with most biomedical databases, the first step is to identify relevant data from the research community. The Monarch Initiative is focused primarily on phenotype-related resources. We bring in data associated with those phenotypes so that our users can begin to make connections among other biological entities of interest. We import data from a variety of data sources. With many resources integrated into a single database, we can join across the various data sources to produce integrated views. We have started with the big players including ClinVar and OMIM, but are equally interested in boutique databases. You can learn more about the sources of data that populate our system from our data sources page
Morph·D·Base has been developed to serve scientific research and education. It provides a platform for storing the detailed documentation of all material, methods, procedures, and concepts applied, together with the specific parameters, values, techniques, and instruments used during morphological data production. In other words, it's purpose is to provide a publicly available resource for recording and documenting morphological metadata. Moreover, it is also a repository for different types of media files that can be uploaded in order to serve as support and empirical substantiation of the results of morphological investigations. Our long-term perspective with Morph·D·Base is to provide an instrument that will enable a highly formalized and standardized way of generating morphological descriptions using a morphological ontology that will be based on the web ontology language (OWL - This, however, represents a project that is still in development.
The main objective of our work is to understand the pathomechanisms of late onset neurodegenerative disorders such as Huntington's, Parkinson's, Alzheimer's and Machado Joseph disease and to develop causal therapies for them. The disease causing proteins of these illnesses have been identified, but their functions in the unaffected organism are mostly unknown. Here, we have developed a strategy combining library and matrix yeast two-hybrid screens to generate a highly connected PPI network for Huntington's disease (HD).
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"IndExs" is a database comprising information on titles, abbreviations and bibliography of exsiccatae. Exsiccatae are defined as "published, uniform, numbered sets of preserved specimens distributed with printed labels" (Pfister 1985). Please note that there are two similar latin terms: "exsiccata, ae" is feminine and used for a set of dried specimens as defined above, whereas the term "exsiccatum, i" is neutral and used for dried specimens in general. You may search "IndExs" using title, part of the title, editor and group of organisms alone or combined. The single search result gives you an unique identifier of the series and all bibliographically important information on the series: the editor(s), title in its bibliographical correct form, standardized abbreviation of the series as to cite in specimen lists of scientific papers, the place of publication and the group(s) of organisms distributed. Additionally, the first and last number of the series as well as the corresponding year of the first and last issue are mentioned. Where preceding and / or superseding series do exist this information is linked. The database also provides access to information about the presence of the series in the herbarium M. As exsiccatae in M are not kept as bibliographically distinct units, but included in the general collections, this indication does not tell anything about the completeness of the set in M. If available, for each series one examplary label is added as image to give layout information. The images are from material located in the herbaria M (the majority), ASU, B, BM, BOUM, BR, BRIX, BUCM, CUP, DR, E, FR, G, GOET, GZU, H, HAL, IB, IBF, JE, K, KR, LD, MO, MSB, NMW, PRC, S, STU, TU, UC, UPS and several others.
In the framework of the Collaborative Research Centre/Transregio 32 ‘Patterns in Soil-Vegetation-Atmosphere Systems: Monitoring, Modelling, and Data Assimilation’ (CRC/TR32,, funded by the German Research Foundation from 2007 to 2018, a RDM system was self-designed and implemented. The so-called CRC/TR32 project database (TR32DB, is operating online since early 2008. The TR32DB handles all data including metadata, which are created by the involved project participants from several institutions (e.g. Universities of Cologne, Bonn, Aachen, and the Research Centre Jülich) and research fields (e.g. soil and plant sciences, hydrology, geography, geophysics, meteorology, remote sensing). The data is resulting from several field measurement campaigns, meteorological monitoring, remote sensing, laboratory studies and modelling approaches. Furthermore, outcomes of the scientists such as publications, conference contributions, PhD reports and corresponding images are collected in the TR32DB.
The database MORPHYLL contains quantitative and qualitative morphometric data of fossil angiosperm leaves from the Paleogene. The data are compiled from different fossil sites housed in various European Natural History Museums.
Open Research Data provides quality assessed data and their metadata such as context information on measurement objectives, equipment, methods, testing and investigation areas. The purpose of the repository is to secure quality, integrity and long-term availability of landscape and ecosystem research data as well as to enhance accessibility of free data from ZALF long-term monitoring campaigns, landscape laboratories (Agro-ScapeLabs), field trials and experiments. The Leibniz Centre for Agricultural Landscape Research (ZALF) explores ecosystems in agricultural landscapes and the development of ecologically and economically viable land use systems. ZALF combines scientific expertise from agricultural science, geosciences, biosciences and socio-economics.
MetaCrop is a database that summarizes diverse information about metabolic pathways in crop plants and allows automatic export of information for the creation of detailed metabolic models. MetaCrop is a database that contains manually curated, highly detailed information about metabolic pathways in crop plants, including location information, transport processes and reaction kinetics.
The IMPC is a confederation of international mouse phenotyping projects working towards the agreed goals of the consortium: To undertake the phenotyping of 20,000 mouse mutants over a ten year period, providing the first functional annotation of a mammalian genome. Maintain and expand a world-wide consortium of institutions with capacity and expertise to produce germ line transmission of targeted knockout mutations in embryonic stem cells for 20,000 known and predicted mouse genes. Test each mutant mouse line through a broad based primary phenotyping pipeline in all the major adult organ systems and most areas of major human disease. Through this activity and employing data annotation tools, systematically aim to discover and ascribe biological function to each gene, driving new ideas and underpinning future research into biological systems; Maintain and expand collaborative “networks” with specialist phenotyping consortia or laboratories, providing standardized secondary level phenotyping that enriches the primary dataset, and end-user, project specific tertiary level phenotyping that adds value to the mammalian gene functional annotation and fosters hypothesis driven research; and Provide a centralized data centre and portal for free, unrestricted access to primary and secondary data by the scientific community, promoting sharing of data, genotype-phenotype annotation, standard operating protocols, and the development of open source data analysis tools. Members of the IMPC may include research centers, funding organizations and corporations.
SeSam is an outstanding international collection of recent and fossil animals and plants from all over the world. It also holds an important specialized library. The really substantial data of this collection constitute the basis of every taxonomic-systematical, ecological, biogeographical or biostratigraphical fundamental research as well as every practical environmental research. Because of its historical referencings this collection is also a precious cultural treasure that generates the often expensive heavy mission of its conservation.