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Found 10 result(s)
As with most biomedical databases, the first step is to identify relevant data from the research community. The Monarch Initiative is focused primarily on phenotype-related resources. We bring in data associated with those phenotypes so that our users can begin to make connections among other biological entities of interest. We import data from a variety of data sources. With many resources integrated into a single database, we can join across the various data sources to produce integrated views. We have started with the big players including ClinVar and OMIM, but are equally interested in boutique databases. You can learn more about the sources of data that populate our system from our data sources page https://monarchinitiative.org/about/sources.
The IMPC is a confederation of international mouse phenotyping projects working towards the agreed goals of the consortium: To undertake the phenotyping of 20,000 mouse mutants over a ten year period, providing the first functional annotation of a mammalian genome. Maintain and expand a world-wide consortium of institutions with capacity and expertise to produce germ line transmission of targeted knockout mutations in embryonic stem cells for 20,000 known and predicted mouse genes. Test each mutant mouse line through a broad based primary phenotyping pipeline in all the major adult organ systems and most areas of major human disease. Through this activity and employing data annotation tools, systematically aim to discover and ascribe biological function to each gene, driving new ideas and underpinning future research into biological systems; Maintain and expand collaborative “networks” with specialist phenotyping consortia or laboratories, providing standardized secondary level phenotyping that enriches the primary dataset, and end-user, project specific tertiary level phenotyping that adds value to the mammalian gene functional annotation and fosters hypothesis driven research; and Provide a centralized data centre and portal for free, unrestricted access to primary and secondary data by the scientific community, promoting sharing of data, genotype-phenotype annotation, standard operating protocols, and the development of open source data analysis tools. Members of the IMPC may include research centers, funding organizations and corporations.
IAGOS aims to provide long-term, regular and spatially resolved in situ observations of the atmospheric composition. The observation systems are deployed on a fleet of 10 to 15 commercial aircraft measuring atmospheric chemistry concentrations and meteorological fields. The IAGOS Data Centre manages and gives access to all the data produced within the project.
Codex Sinaiticus is one of the most important books in the world. Handwritten well over 1600 years ago, the manuscript contains the Christian Bible in Greek, including the oldest complete copy of the New Testament. The Codex Sinaiticus Project is an international collaboration to reunite the entire manuscript in digital form and make it accessible to a global audience for the first time. Drawing on the expertise of leading scholars, conservators and curators, the Project gives everyone the opportunity to connect directly with this famous manuscript.
DEPOD - the human DEPhOsphorylation Database (version 1.1) is a manually curated database collecting human active phosphatases, their experimentally verified protein and non-protein substrates and dephosphorylation site information, and pathways in which they are involved. It also provides links to popular kinase databases and protein-protein interaction databases for these phosphatases and substrates. DEPOD aims to be a valuable resource for studying human phosphatases and their substrate specificities and molecular mechanisms; phosphatase-targeted drug discovery and development; connecting phosphatases with kinases through their common substrates; completing the human phosphorylation/dephosphorylation network.
The FAIRDOMHub is built upon the SEEK software suite, which is an open source web platform for sharing scientific research assets, processes and outcomes. FAIRDOM (Web Site) will establish a support and service network for European Systems Biology. It will serve projects in standardizing, managing and disseminating data and models in a FAIR manner: Findable, Accessible, Interoperable and Reusable. FAIRDOM is an initiative to develop a community, and establish an internationally sustained Data and Model Management service to the European Systems Biology community. FAIRDOM is a joint action of ERA-Net EraSysAPP and European Research Infrastructure ISBE.
Welcome to INTERMAGNET - the global network of observatories, monitoring the Earth's magnetic field. At this site you can find data and information from geomagnetic observatories around the world. The INTERMAGNET programme exists to establish a global network of cooperating digital magnetic observatories, adopting modern standard specifications for measuring and recording equipment, in order to facilitate data exchanges and the production of geomagnetic products in close to real time.
When published in 2005, the Millennium Run was the largest ever simulation of the formation of structure within the ΛCDM cosmology. It uses 10(10) particles to follow the dark matter distribution in a cubic region 500h(−1)Mpc on a side, and has a spatial resolution of 5h−1kpc. Application of simplified modelling techniques to the stored output of this calculation allows the formation and evolution of the ~10(7) galaxies more luminous than the Small Magellanic Cloud to be simulated for a variety of assumptions about the detailed physics involved. As part of the activities of the German Astrophysical Virtual Observatory we have created relational databases to store the detailed assembly histories both of all the haloes and subhaloes resolved by the simulation, and of all the galaxies that form within these structures for two independent models of the galaxy formation physics. We have implemented a Structured Query Language (SQL) server on these databases. This allows easy access to many properties of the galaxies and halos, as well as to the spatial and temporal relations between them. Information is output in table format compatible with standard Virtual Observatory tools. With this announcement (from 1/8/2006) we are making these structures fully accessible to all users. Interested scientists can learn SQL and test queries on a small, openly accessible version of the Millennium Run (with volume 1/512 that of the full simulation). They can then request accounts to run similar queries on the databases for the full simulations. In 2008 and 2012 the simulations were repeated.
CARIBIC is an innovative scientific project to study and monitor important chemical and physical processes in the Earth´s atmosphere. Detailed and extensive measurements are made during long distance flights. We deploy an airfreight container with automated scientific apparatus which are connected to an air and particle (aerosol) inlet underneath the aircraft. We use an Airbus A340-600 from Lufthansa since December 2004.
Including data and software from CrystalEye is this a open-access collection of crystal structures of organic, inorganic, metal-organic compounds and minerals, excluding biopolymers. At present, this is the most comprehensive open resource for small molecule structures, freely available to all scientists in Lithuania and worldwide. Including data and software from CrystalEye, developed by Nick Day at the department of Chemistry, the University of Cambridge under supervision of Peter Murray-Rust.