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GENCODE is a scientific project in genome research and part of the ENCODE (ENCyclopedia Of DNA Elements) scale-up project. The GENCODE consortium was initially formed as part of the pilot phase of the ENCODE project to identify and map all protein-coding genes within the ENCODE regions (approx. 1% of Human genome). Given the initial success of the project, GENCODE now aims to build an “Encyclopedia of genes and genes variants” by identifying all gene features in the human and mouse genome using a combination of computational analysis, manual annotation, and experimental validation, and annotating all evidence-based gene features in the entire human genome at a high accuracy.
The primary goal of GeneDB is to provide access to genome annotation for species that are undergoing manual curation and refinement. The site is updated monthly to reflect close to real-time changes in annotation, before they have been propagated across EuPathDB and other sites with whom we collaborate. Annotations reflect changes made in-house by scientists, as part of their research projects, and by dedicated curators based in-house and in collaborating organisations.