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Giardia lamblia is a significant, environmentally transmitted, human pathogen and an amitochondriate protist. It is a major contributor to the enormous worldwide burden of human diarrheal diseases, yet the basic biology of this parasite is not well understood. No virulence factor has been identified. The Giardia lamblia genome contains only 12 million base pairs distributed onto five chromosomes. Its analysis promises to provide insights about the origins of nuclear genome organization, the metabolic pathways used by parasitic protists, and the cellular biology of host interaction and avoidance of host immune systems. Since the divergence of Giardia lamblia lies close to the transition between eukaryotes and prokaryotes in universal ribosomal RNA phylogenies, it is a valuable, if not unique, model for gaining basic insights into genetic innovations that led to formation of eukaryotic cells. In evolutionary terms, the divergence of this organism is at least twice as ancient as the common ancestor for yeast and man. A detailed study of its genome will provide insights into an early evolutionary stage of eukaryotic chromosome organization as well as other aspects of the prokaryotic / eukaryotic divergence.
EuPathDB (formerly ApiDB) is an integrated database covering the eukaryotic pathogens in the genera Acanthamoeba, Annacaliia, Babesia, Crithidia, Cryptosporidium, Edhazardia, Eimeria, Encephalitozoon, Endotrypanum, Entamoeba, Enterocytozoon, Giardia, Gregarina, Hamiltosporidium, Leishmania, Nematocida, Neospora, Nosema, Plasmodium, Theileria, Toxoplasma, Trichomonas, Trypanosoma and Vavraia, Vittaforma). While each of these groups is supported by a taxon-specific database built upon the same infrastructure, the EuPathDB portal offers an entry point to all of these resources, and the opportunity to leverage orthology for searches across genera.
The CDAWeb data system enables improved display and coordinated analysis of multi-instrument, multimission data bases of the kind whose analysis is critical to meeting the science objectives of the ISTP program and the InterAgency Consultative Group (IACG) Solar-Terrestrial Science Initiative. The system combines the client-server user interface technology of the World Wide Web with a powerful set of customized IDL routines to leverage the data format standards (CDF) and guidelines for implementation adopted by ISTP and the IACG. The system can be used with any collection of data granules following the extended set of ISTP/IACG standards. CDAWeb is being used both to support coordinated analysis of public and proprietary data and better functional access to specific public data such as the ISTP-precursor CDAW 9 data base that is formatted to the ISTP/IACG standards. Many data sets are available through the Coordinated Data Analysis Web (CDAWeb) service and the data coverage continues to grow. These are largely, but not exclusively, magnetospheric data and nearby solar wind data of the ISTP era (1992-present) at time resolutions of approximately a minute. The CDAWeb service provides graphical browsing, data subsetting, screen listings, file creations and downloads (ASCII or CDF). Public data from current (1992-present) space physics missions (including Cluster, IMAGE, ISTP, FAST, IMP-8, SAMPEX and others). Public data from missions before 1992 (including IMP-8, ISIS1/2, Alouette2, Hawkeye and others). Public data from all current and past space physics missions. CDAWeb ist part of "Space Physics Data Facility" (https://www.re3data.org/repository/r3d100010168).
The Deep Carbon Observatory (DCO) is a global community of multi-disciplinary scientists unlocking the inner secrets of Earth through investigations into life, energy, and the fundamentally unique chemistry of carbon. Deep Carbon Observatory Digital Object Registry (“DCO-VIVO”) is a centrally-managed digital object identification, object registration and metadata management service for the DCO. Digital object registration includes DCO-ID generation based on the global Handle System infrastructure and metadata collection using VIVO. Users will be able to deposit their data into the DCO Data Repository and have that data discoverable and accessible by others.
AmphibiaWeb is an online system enabling any user to search and retrieve information relating to amphibian biology and conservation. This site was motivated by the global declines of amphibians, the study of which has been hindered by the lack of multidisplinary studies and a lack of coordination in monitoring, in field studies, and in lab studies. We hope AmphibiaWeb will encourage a shared vision to collaboratively face the challenge of global amphibian declines and the conservation of remaining amphibians and their habitats.